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Join us if you are looking for love and meet gay men in Lafayette County. Aspirin-induced gastrointestinal injury in patients with alcoholic hepatitis. Aspirin causes gastric mucosal damage and is associated with peptic ulceration, gastroduodenal bleeding, and anemia. There are limited data on gastric injury caused by aspirin in alcoholic patients. Our study sought to determine the incidence of aspirin-induced gastric damage in patients with alcoholic hepatitis. We conducted a prospective study of 60 male patients with alcoholic hepatitis and 60 healthy male subjects. Exclusion criteria included any history of pancreatitis, renal failure, or peptic ulceration. All subjects consumed aspirin 100 mg qid for 3 days and underwent endoscopy after aspirin consumption. We measured serum pepsinogen, pepsinogen I, and pepsinogen II levels and performed upper endoscopy to detect aspirin-induced injury. The prevalence of aspirin-induced gastrointestinal damage was significantly more frequent in patients with alcoholic hepatitis than in healthy subjects (37.6% versus 24%). In patients with alcoholic hepatitis, those who experienced gastrointestinal injury had higher serum alanine aminotransferase values and histologic features of higher alcohol intake than those who did not experience gastrointestinal injury. In contrast, there were no correlations between other clinical characteristics and gastrointestinal injury.

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